Quinone Reductase

Quinones, a class of organic compounds, are formally derived from aromatic compounds and are a subset of the quinoid family which also contains the quinone imines and the quinone methides. NQO1 (QR1, EC 1.6.99.2), also referred to as DT-diaphorase (formerly), nicotinamide quinone oxidoreductase 1, quinone reductase type 1, or menadione reductase, is a cytosolic flavoenzyme. Another member of the quinone oxidoreductases family is NQO2 (QR2, EC 1.10.99.2) which is also a FAD bound protein (25 kDa) and closely related to NQO1. In addition to NQO1 and NQO2 found in humans, an ancient NQO3 subfamily exists in eubacteria, NQO4 subfamily in fungi, and NQO5 subfamily in archaebacteria^[1]^[2].

References:

[1]. Rashid MH, et al. Interactions of the antioxidant enzymes NAD(P)H: Quinone oxidoreductase 1 (NQO1) and NRH: Quinone oxidoreductase 2 (NQO2) with pharmacological agents, endogenous biochemicals and environmental contaminants. Chem Biol Interact. 2021 Aug 25;345:109574.

[2]. Cuendet M, et al. Quinone reductase induction as a biomarker for cancer chemoprevention. J Nat Prod. 2006 Mar;69(3):460-3.

Quinone Reductase Related Products (3):

By Effects:	Substrate (1) Activator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-114315

NQO1 substrate	Substrate	98.02%
NQO1 substrate acts as an efficient NQO1 substrate and may be a new option for the treatment of NQO1-overexpresssing drug-resistant NSCLC.

HY-123903

Tanshindiol B	Activator
Tanshindiol B, a naphthaquinone diterpene, inhibits glioblastoma (GBM) growth by induction of noptosis (NQO1-dependent necrosis).

HY-121425

Dunnione
Dunnione (CompoundⅠ) is a pigment. Dunnione can be isolated from the leaves of Didymocarpus pedicellata.

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